Research overview

Our lab is interested in molecular and cellular mechanisms of Alzheimer's disease pathogenesis with two major areas of research focus. First, we investigate the cell biology of two proteases, termed BACE1 and gamma-secretase, which sequentially cleave amyloid precursor protein (APP) to generate Aß peptides. BACE1 is a type I transmembrane aspartyl protease, whereas gamma-secretase is a multiprotein transmembrane complex made of the catalytic subunit presenilin (PS1 or PS2) and three other integral subunits: nicastrin, APH-1 and PEN-2. Second, we are interested in the functional characterization of biological pathways and pathogenic mechanisms regulated by recently-identified GWAS risk genes. We use cultured neuronal and non-neuronal cell lines, primary neurons, knock out/knock-in/transgenic mouse models in our investigations.

Latest News and Announcements

Pictures from Around the Lab

Around the lab

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Rob receives IDPH Award

Congratulations to Rob on his fellowship award!

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Pierre receives BrightFocus Foundation Award

Congratulations to Pierre on his award!

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New Lab Member

Welcome!

Graduate Student Intern from France - Andrea Isasi University of Health, Sciences and Technologies – Bordeaux, France

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Rob receives a best poster award

Congratulations to Rob for winning a best poster award at the 17th Annual Neuroscience Day held on Friday, April 7, 201 at the Lurie Medical Research Center, Northwestern University.

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Pierre receives a grant from Alzheimer's Association

Congratulations to Pierre on his Alzheimer's Association Research Fellowship Award!

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Recent Publications

Congratulations to Pierre and Virginie!

- our second paper on BIN1  is published on Science Matters

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Virginie moves to a new job

Congratulations to Virginie!

She has moved to Houston to lead AD drug discovery efforts.

She is now the Research Scientist, Head of Neuroscience target discovery and validation at MD Anderson Cancer Center.

We wish her the best.

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Virginie wins Best Poster Award at the BRF Neuroscience Day

          Congratulations!

Virginie Buggia-Prévot won a Best Poster Award at the The 15th Annual Neuroscience Day held on Friday, January 23, 2015 at the Lurie Medical Research Center, Northwestern University.

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Medicine on the Midway

Our research on BACE1 is featured on page 8 of the Spring 2014 issue. Congratulations to Virginie and Celia.

Link:  Story  /  Spring 2014 issue

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Virginie receives a BrightFocus Fellowship

Congratulations to Virginie for receiving a                                                 BrightFocus Research Fellowship Award!

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Virginie on the Spotlight

Virginie's accomplishments are highlighted on the Postdoc Spotlight

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Celia presents her research to CON applicants

Celia Fernandez gives a research presentation to Comittee on Neurobiology applicants

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Celia wins Best Poster Award - again!

Congratulations!

Celia Fernandez won a Best Poster Award, second year in a row at the The 14th Annual Neuroscience Day held on Friday, January 17, 2014 at the Lurie Medical Research Center of Northwestern University. 

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Science Life Blog about our research

Shedding Light on a New Mechanism Behind Alzheimer’s Disease

Posted by Kevin Jiang on January 14, 2014 in Neuroscience

New findings about a key enzyme in the development of Alzheimer’s could point to new way of targeting an important protein for therapies.

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Molecular Neurodegeneration publication

Virgine and Celia's research on BACE1 was published on January 4, 2014 in Molecular Neurodegeneration

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Cell Reports publication

Virgine and Celia's research on BACE1 was published on December 26 in Cell Reports.  Read a summary here: http://neurobiology.uchicago.edu/

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