Research overview

Our lab is interested in molecular and cellular mechanisms of Alzheimer's disease pathogenesis. The overarching goal of our research is to gain insights from cutting-edge cell biology investigations and translate our discoveries to advance therapeutic strategies that can reduce Alzheimer's disease neuropathology and mitigate cognitive deficits in Alzheimer's disease. A primary focus of our research is the neuronal mechanisms responsible for amyloid pathology and Alzheimer’s disease-related axonal transport defects. Here, we study APP metabolism, neuronal trafficking of APP and BACE1, and axonal transport dysfunction. The second focus of our research is to characterize the biological pathways and pathogenic mechanisms regulated by the second most common late-onset Alzheimer’s disease risk factor, BIN1. Recently, we began to investigate molecular mechanisms underlying the interaction of amylin with Aβ pathology in order to explore the molecular link between type-2 diabetes and Alzheimer's disease. My group uses an integrated approach that combines hypothesis-driven mutagenesis, biochemical and pathological characterization, detailed subcellular localization, advanced live-cell imaging, superresolution microscopy, electrophysiology, and mouse behavior analysis to accomplish our goals. Cultured primary hippocampal neurons and oligodendrocytes, established cell lines, transgenic mice, and conditional knockout mice serve as experimental models in our investigation.

Latest News and Announcements

Recent publications

Congratulations to Andrew et al. Our manuscript "Reduction of the expression of the late-onset Alzheimer’s disease (AD) risk-factor BIN1 does not affect amyloid pathology in an AD mouse model" published in Journal of Biological Chemistry is available online now. PDF of the paper is here: http://www.jbc.org/content/early/2019/01/28/jbc.RA118.006379.abstract

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New Lab Members

Welcome!

Jean-Michel Paumier - Postdoctoral Scholar

Jean-Michel joined our group in the beginning of March. He received his Ph.D. from Aix-Marseille University, AMU/CNRS Marseille, France. His thesis is entitled "Matrix metalloproteinases and Alzheimer’s disease : Study of the roles of MT1- and MT5-MMP in amyloidogenesis and neuroinflammation"

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Holiday Lunch 2018 / Lab BBQ

Our 2018 Holiday Lunch pictures are here \

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Congratulations to Rob and Celia on their PNAS paper!

Our manuscript characterizing S-palmitoylation of BACE using KI mice has been published in the Proceedings of the National Academy of Sciences.Manuscript Link

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Pictures from Around the Lab

Around the lab

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Rob receives IDPH Award

Congratulations to Rob on his fellowship award!

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Pierre receives BrightFocus Foundation Award

Congratulations to Pierre on his award!

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Rob receives a best poster award

Congratulations to Rob for winning a best poster award at the 17th Annual Neuroscience Day held on Friday, April 7, 201 at the Lurie Medical Research Center, Northwestern University.

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Pierre receives a grant from Alzheimer's Association

Congratulations to Pierre on his Alzheimer's Association Research Fellowship Award!

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Recent Publications

Congratulations to Pierre and Virginie!

- our second paper on BIN1  is published on Science Matters

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Virginie moves to a new job

Congratulations to Virginie!

She has moved to Houston to lead AD drug discovery efforts.

She is now the Research Scientist, Head of Neuroscience target discovery and validation at MD Anderson Cancer Center.

We wish her the best.

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Virginie wins Best Poster Award at the BRF Neuroscience Day

          Congratulations!

Virginie Buggia-Prévot won a Best Poster Award at the The 15th Annual Neuroscience Day held on Friday, January 23, 2015 at the Lurie Medical Research Center, Northwestern University.

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Medicine on the Midway

Our research on BACE1 is featured on page 8 of the Spring 2014 issue. Congratulations to Virginie and Celia.

Link:  Story  /  Spring 2014 issue

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Virginie receives a BrightFocus Fellowship

Congratulations to Virginie for receiving a                                                 BrightFocus Research Fellowship Award!

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Virginie on the Spotlight

Virginie's accomplishments are highlighted on the Postdoc Spotlight

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Celia presents her research to CON applicants

Celia Fernandez gives a research presentation to Comittee on Neurobiology applicants

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Celia wins Best Poster Award - again!

Congratulations!

Celia Fernandez won a Best Poster Award, second year in a row at the The 14th Annual Neuroscience Day held on Friday, January 17, 2014 at the Lurie Medical Research Center of Northwestern University. 

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Science Life Blog about our research

Shedding Light on a New Mechanism Behind Alzheimer’s Disease

Posted by Kevin Jiang on January 14, 2014 in Neuroscience

New findings about a key enzyme in the development of Alzheimer’s could point to new way of targeting an important protein for therapies.

Read the full story here.

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Molecular Neurodegeneration publication

Virgine and Celia's research on BACE1 was published on January 4, 2014 in Molecular Neurodegeneration

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Cell Reports publication

Virgine and Celia's research on BACE1 was published on December 26 in Cell Reports.  Read a summary here: http://neurobiology.uchicago.edu/

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