Science Life Blog about our PNAS paper
Slight genetic changes can limit production of Alzheimer’s disease plaques
Read the Science Life blog here
Posted on October 23, 2017 by Matt Wood
Our lab is interested in molecular and cellular mechanisms of Alzheimer's disease pathogenesis with two major areas of research focus. First, we investigate the cell biology of two proteases, termed BACE1 and gamma-secretase, which sequentially cleave amyloid precursor protein (APP) to generate Aß peptides. BACE1 is a type I transmembrane aspartyl protease, whereas gamma-secretase is a multiprotein transmembrane complex made of the catalytic subunit presenilin (PS1 or PS2) and three other integral subunits: nicastrin, APH-1 and PEN-2. Second, we are interested in the functional characterization of biological pathways and pathogenic mechanisms regulated by recently-identified GWAS risk genes. We use cultured neuronal and non-neuronal cell lines, primary neurons, knock out/knock-in/transgenic mouse models in our investigations.
Ian Weigle - Research Technologist
Ha-Na Shim - Research Technologist
Mary Frith - MSTP Student (lab rotation)
Hannah Martin - Neurobiology Graduate Student (lab rotation)
Charlotte Goldberger - High School Volunteer (UC Lab School)
Our manuscript characterizing S-palmitoylation of BACE using KI mice has been published in the Proceedings of the National Academy of Sciences.Manuscript Link
Congratulations to Rob on his fellowship award!
Congratulations to Pierre on his award!
Congratulations to Rob for winning a best poster award at the 17th Annual Neuroscience Day held on Friday, April 7, 201 at the Lurie Medical Research Center, Northwestern University.
Congratulations to Pierre on his Alzheimer's Association Research Fellowship Award!
- our second paper on BIN1 is published on Science Matters
She has moved to Houston to lead AD drug discovery efforts.
She is now the Research Scientist, Head of Neuroscience target discovery and validation at MD Anderson Cancer Center.
We wish her the best.
Virginie Buggia-Prévot won a Best Poster Award at the The 15th Annual Neuroscience Day held on Friday, January 23, 2015 at the Lurie Medical Research Center, Northwestern University.
Our research on BACE1 is featured on page 8 of the Spring 2014 issue. Congratulations to Virginie and Celia.
Congratulations to Virginie for receiving a BrightFocus Research Fellowship Award!
Virginie's accomplishments are highlighted on the Postdoc Spotlight
Celia Fernandez gives a research presentation to Comittee on Neurobiology applicants
Celia Fernandez won a Best Poster Award, second year in a row at the The 14th Annual Neuroscience Day held on Friday, January 17, 2014 at the Lurie Medical Research Center of Northwestern University.
Posted by Kevin Jiang on January 14, 2014 in Neuroscience
New findings about a key enzyme in the development of Alzheimer’s could point to new way of targeting an important protein for therapies.
Virgine and Celia's research on BACE1 was published on January 4, 2014 in Molecular Neurodegeneration