Cell Reports publication

A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer’s Disease Aβ Production

Cell Reports, Volume 5, Issue 6, 1552-1563, 26 December 2013
Download the PDF here: Buggia-Prévot et al.
Live imaging videos can be viewed here:  YouTubeLogo copy.jpg

Highlights

  • Endocytosed BACE1 undergoes exclusive retrograde transport to the soma in dendrites
  • EHD1 and EHD3 regulate unidirectional dendritic transport of internalized BACE1
  • Axonal sorting and transport of BACE1 are impaired when EHD function is compromised
  • Knockdown of EHD1 and EHD3 expression attenuates Aβ secretion in neurons