Molecular Neurodegeneration publication

Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase

Molecular Neurodegeneration 2014, 9:1
Download the PDF here: Buggia-Prévot et al.
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Conclusions of this paper:
Our results reveal novel information on dynamic BACE1 transport in neurons, and demonstrate that Rab11-GTPase function is critical for axonal sorting of BACE1. Thus, we suggest that BACE1 transcytosis in endosomes contributes to presynaptic BACE1 localization.