Publications

                                                PubMed link for a list of all publications

Selected Publications

Andrew RJ, Fernandez CG, Stanley M, Jiang H, Nguyen P, Rice RC, Buggia-Prévot V, De Rossi P, Vetrivel KS, Lamb R, Argemi A, Allaert ES, Rathbun EM, Krause SV, Wagner SL, Parent AT, Holtzman DM, and Thinakaran G: Lack of BACE1 S-palmitoylation reduces amyloid burden and mitigates memory deficits in transgenic mouse models of Alzheimer’s disease. . Proc. Natl. Acad. Sci. USA. Full Text

Maulik M, Vergote D, Phukan G, Chung J, Thinakaran G, and Kar S: The effects of extracellular serum concentration on APP processing in Npc1-deficient-APP overexpressing N2a cells. Mol. Neurobiol. Full Text

De Rossi P, Buggia-Prévot V, Andrew RJ, Krause SV, Woo E, Nelson PT, Pytel P, and Thinakaran G: BIN1 localization is distinct from Tau tangles in Alzheimer’s disease. Matters, 2017. Full Text

De Rossi P, Buggia-Prévot V, Clayton BLL, Vasquez JB, van Sanford C, Andrew RJ, Lesnick R, Botté A, Deyts C, Salem S, Rao E, Rice RC, Parent A, Kar S, Popko B, Pytel P, Estus S, and Thinakaran G: Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts. Mol. Neurodegener. 2016, 11:59. DOI 10.1186/s13024-016-0124-1. Full Text

Sadleir KR, Kandalepas PC, Buggia-Prévot V, Nicholson DA, Thinakaran G, and Vassar R: Presynaptic dystrophic neurites surrounding amyloid plaques are sites of microtubule disruption, BACE1 elevation, and increased Aβ generation in Alzheimer's disease. Acta Neuropathol. 132: 235-256, 2016. Abstract

Andrew RJ, Kellett KA, Thinakaran G, and Hooper NM: A Greek Tragedy: the Growing Complexity of Alzheimer Amyloid Precursor Protein Proteolysis. J. Biol. Chem. 2016, 291(37):19235-44. Abstract

Buggia-Prévot V and Thinakaran G: Significance of transcytosis in Alzheimer’s disease: BACE1 takes the scenic route to axons. Bioessays. 37:888-98, 2015. Full Text

Wang Y, Buggia-Prévot, Zavorka ME, Bleackley RC, MacDonald RG, Thinakaran G, and Kar S: Overexpression of the Insulin-Like Growth Factor-II Receptor Increases β-amyloid Production and Affects Cell Viability. Mol. Cell Biol. 35: 2368-84, 2015. Abstract

Buggia-Prévot V and Thinakaran G: Sorting the role of SORLA in Alzheimer's disease. Sci. Transl. Med. 6, 223fs8, 2014. Full Text / PDF

Buggia-Prévot V, Fernandez CG, Riordan S, Vetrivel KS, Roseman J, Waters J, Bindokas VP, Vassar R, and Thinakaran G: Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Molecular Neurodegeneration 9(1):1, 2014. Full Text

Buggia-Prévot V, Fernandez CG, Udayar V, Vetrivel KS, Elie A, Roseman J, Sasse VA, Lefkow M, Meckler X, Bhattacharyya S, George M, Kar S, Bindokas VP, Parent AT, Rajendran L, Band H, Vassar R and Thinakaran G: A Function for EHD Family Proteins in Unidirectional Retrograde Dendritic Transport of BACE1 and Alzheimer's Disease Aβ production. Cell Reports 5:1552–1563, 2013. Full Text / PDF / Movies 

Udayar V, Buggia-Prévot V, Guerreiro RL, Siegel G, Rambabu N, Soohoo AL, Ponnuswamy M, Siegenthaler B, Bali J, AESG, Simons M, Ries J, Puthenveedu MA, Hardy J, Thinakaran G and Rajendran L: A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production. Cell Reports 5:1536–1551, 2013. Full Text / PDF / Movies

Zeiger W, Vetrivel KS, Buggia-Prévot V, Nguyen PH, Wagner SL, Villereal M and Thinakaran G: Ca2+ influx through store-operated Ca2+ channels reduces Alzheimer’s Disease β-amyloid peptide secretion. J. Biol. Chem. 288: 26955–26966, 2013. PubMed Link

Haass C, Kaether C, Thinakaran G and Sisodia S: Trafficking and Proteolytic Processing of APP. In: Cold Spring Harb Perspect Med. 2012, 2(5):a006270. PDF

Vetrivel KS, Barman A, Chen Y, Nguyen PD, Wagner SL, Prabhakar R, and Thinakaran G: Loss of cleavage at β’-site contributes to the apparent increase of Aβ secretion by BACE1-GPI processing of APP. J. Biol. Chem. 286: 26166–26177, 2011.

Zeiger W, Ito D, Swetlik C, Oh-hora M, Villereal ML, and Thinakaran G: Stanniocalcin 2 is a negative modulator of store-operated calcium entry. Mol. Cell Biol. 18: 3710-22, 2011.

Gong P, Roseman J, Fernandez CG, Vetrivel KS, Bindokas VP, Zitzow LA, Kar S, Parent AT, and Thinakaran G: Transgenic neuronal overexpression reveals that stringently regulated p23 expression is critical for coordinated movement in mice. Mol Neurodegener. 6:87, 2011.

Meckler X, Roseman, J, Das P, Cheng H, Pei S, Keat M, Kassarjian B, Golde TE, Parent AT, and Thinakaran G: Reduced Alzheimer’s disease β-amyloid deposition in transgenic mice expressing S-palmitoylation-deficient APH1aL and nicastrin. J. Neurosci. 30: 16160-16169, 2010.

Gong P, Cheng H, Vetrivel KS, Nguyen PD, Kounnas MZ, Thinakaran G: Mutation analysis of the presenilin 1 N-terminal domain reveals a broad spectrum of γ-secretase activity towards APP and other substrates. J. Biol. Chem. 285: 38042-38052, 2010.

Vetrivel KS, Meckler X, Chen Y, Nguyen PD, Kounnas MZ and Thinakaran G: Alzheimer disease Ab production in the absence of S-palmitoylation-dependent targeting of BACE1 to lipid rafts. J. Biol. Chem. 284:3793-803, 2009.

Chen H, Vetrivel KS, Drisdel R, Li T, Carter M, Gong P, Chen Y, Nguyen PD, Placania L, Li Y-M, Wong PC, Green WN, Kounnas MZ and Thinakaran G: S-palmitoylation of g-secretase subunits. J. Biol. Chem. 284:1373-1384, 2009.

Vetrivel KS, Zhang X, Meckler X, Cheng H, Lee S, Gong P, Chen Y, Iwata| N, Parent A, Saido TC, Li Y, Sisodia SS, Thinakaran G: Evidence that CD147 modulation of Ab levels is mediated by extracellular degradation of secreted Aß. J. Biol. Chem. 283:19489-98, 2008.

Vetrivel KS, Gong P, Bowen JW, Cheng H, Chen Y, Carter M, Nguyen PD, Placanica L, Wieland FT, Li YM, Kounnas MZ and Thinakaran G: Dual roles of the transmembrane protein p23/TMP21 in the modulation of amyloid precursor protein metabolism. Mol Neurodegener. 2007 Feb 8;2(1):4.

Vetrivel KS, Cheng H, Kim SH, Chen Y, Barnes NY, Parent AT, Sisodia SS and Thinakaran G: Spatial segregation of g-secretase and substrates in distinct membrane domains. J. Biol. Chem. 280:25892-25900, 2005.

Ito D, Walker JR, Thompson CS, Moroz I, Lin W, Veselits ML, Hakim AM, Fienberg AA, and Thinakaran G: Characterization of stanniocalcin 2, a novel target of the mammalian unfolded protein response with cytoprotective properties. Mol. Cell. Biol. 24:9456-69, 2004.

Vetrivel KS, Cheng H, Sakurai T, Li T, Nukina N, Wong PC, and Thinakaran G: Association of g-secretase complex with lipid raft microdomains in post-Golgi and endosomes membranes. J. Biol. Chem. 279:44945-44954, 2004.

Sato N, Urano F, Leem J-Y, Kim SH, Donoviel D, Bernstein A, Li M, Lee AS, Ron D, Veselits ML, Sisodia SS and Thinakaran G: Upregulation of BiP and CHOP by the unfolded protein response is independent of presenilin expression. Nature Cell Biol. 2:863-870, 2000.