Gopal Thinakaran

Professor of Neurobiology, Neurology, and Pathology

Born: Sivakasi, India

Education:
B.Sc. (1985) M.Sc. (1987)
     Madurai Kamaraj University, India
Ph.D. in Molecular Biology and Genetics (1992)
     The University of Guelph, Canada

Post-doctoral Fellow (1992-1997)
     Division of Neuropathology, The Johns Hopkins University, Baltimore

Previous Employment:
 Assistant Professor (1997-1999)
     Dept of Pathology, The Johns Hopkins University, Baltimore
Assistant Professor (1999-2002), and Associate Professor (2003-2010)
    Dept of Neurobiology, The University of Chicago

I am a cell biologist interested in molecular and cellular mechanisms of Alzheimer's disease pathogenesis. For over twelve years I have been leading a group at the University of Chicago, investigating multiple aspects of Alzheimer's disease cell biology including, the physiological and pathological functions of presenilins, regulation of APP trafficking and metabolism, modulation of ß-amyloid production/deposition by post-translational modification of APP secretases and interaction with associated proteins, the characterization of subcellular sites and membrane microdomains involved in the generation of ß-amyloid peptides, and the dynamic regulation of ß-secretase BACE1 trafficking in hippocampal neurons.

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