Interested in joining our lab?
Graduate student and post-doctoral fellow positions are available for highly-motivated individuals to study molecular and cellular mechanisms of Alzheimer's disease pathogenesis. We investigate amyloid precursor protein processing, trafficking of amyloid precursor protein and secretases, and disease-associated synaptic abnormalities using neuronal cell culture, transgenic/knock-in/knock-out mouse models. A major focus of our research is to understand the neuronal targeting mechanisms responsible for polarized sorting of the aspartyl protease BACE1, using advanced microscopy approaches. The second focus of our research is to characterize using conditional KO and transgenic mice, the biological pathways and pathogenic mechanisms regulated by the major late-onset Alzheimer’s disease risk gene, BIN1.